Association of Tumor Protein 53 Polymorphism with Esophageal Cancer Cases: A Systematic Review and Meta-Analysis

To investigate the association between tumor protein 53 polymorphism and esophageal cancer cases using systematic review meta-analysis, this provides a basis for future researches. All studies on mutations in patients with its influencing factors, which published before May 2021, were collected by searching Cochrane Library, PubMed, Embase, China National Knowledge Infrastructure Wanfang data. Meta-analysis was performed RevMan 5.3. Ten eligible (Chinese n=7, English n=3) involving 1379 included analysis. showed that odds ratio value (95 % confidence interval) of Caucasian 70.51 (9.77, 508.88), z=4.22, p<0.0001; Chinese Han 1.06 (0.63, 1.79), z=0.22, p=0.83; Uyghur 18.48 (4.44, 76.90), z=4.01, p<0.0001. The 1.01 (0.60, 1.72), z=0.05, p=0.96; deletions 23.02 (9.04, 58.63), z=6.57, p≤0.00001. There no significant difference control group. is certain correlation incidence change gene will affect risk prognosis cancer.